Unit circle MVDR beamformer

The array polynomial is the z-transform of the array weights for a narrowband planewave beamformer using a uniform linear array (ULA). Evaluating the array polynomial on the unit circle in the complex plane yields the beampattern. The locations of the polynomial zeros on the unit circle indicate the nulls of the beampattern. For planewave signals measured with a ULA, the locations of the ensemble MVDR polynomial zeros are constrained on the unit circle. However, sample matrix inversion (SMI) MVDR polynomial zeros generally do not fall on the unit circle. The proposed unit circle MVDR (UC MVDR) projects the zeros of the SMI MVDR polynomial radially on the unit circle. This satisfies the constraint on the zeros of ensemble MVDR polynomial. Numerical simulations show that the UC MVDR beamformer suppresses interferers better than the SMI MVDR and the diagonal loaded MVDR beamformer and also improves the white noise gain (WNG).Comment: Accepted to ICASSP 201

Implementation and evaluation of a dual-sensor time-adaptive EM algorithm for signal enhancement

Submitted in partial fulfillment of the requirements for the degree of Master of Science at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution August 1991This thesis describes the implementation and evaluation of an adaptive time-domain algorithm for signal enhancement from multiple-sensor observations. The algorithm is first derived as a noncausal time-domain algorithm, then converted into a causal, recursive form. A more computationally efficient gradient-based parameter estimation step is also presented. The results of several experiments using synthetic data are shown. These experiments first illustrate that the algorithm works on data meeting all the assumptions made by the algorithm, then provide a basis for comparing the performance of the algorithm against the performance of a noncausal frequency-domain algorithm solving the same problem. Finally, an evaluation is made of the performance of the simpler gradient-based parameter estimation step

Single mode excitation in the shallow water acoustic channel using feedback control

Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution June 1996The shallow water acoustic channel supports far-field propagation in a discrete set of modes. Ocean experiments have confirmed the modal nature of acoustic propagation, but no experiment has successfully excited only one of the suite of mid-frequency propagating modes propagating in a coastal environment. The ability to excite a single mode would be a powerful tool for investigating shallow water ocean processes. A feedback control algorithm incorporating elements of adaptive estimation, underwater acoustics, array processing and control theory to generate a high-fidelity single mode is presented. This approach also yields a cohesive framework for evaluating the feasibility of generating a single mode with given array geometries, noise characteristics and source power limitations. Simulations and laboratory waveguide experiments indicate the proposed algorithm holds promise for ocean experiments.Josko Catipovic funded my research for summer of 1992 on the Office of Naval Research Grant Number N00014-92-J-1661 and from June 1993 through August 1995 on Defense Advanced Research Projects Agency Grant Number MDA972-92-J- 1041. The Office of Naval Research Grant N00014-95-1-0362 to MIT supported the computer facilities used to do much of this work

Single mode excitation in the shallow water acoustic channel using feedback control

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.Includes bibliographical references (p. 127-134).by John R. Buck.Ph.D

Prevalence of non-aureus Staphylococcus species causing intramammary infections in Canadian dairy herds

Non-aureus staphylococci (NAS), the microorganisms most frequently isolated from bovine milk worldwide, are a heterogeneous group of numerous species. To establish their importance as a group, the distribution of individual species needs to be determined. In the present study, NAS intramammary infection (IMI) was defined as a milk sample containing ≥1,000 cfu/mL in pure or mixed culture that was obtained from a cohort of cows assembled by the Canadian Bovine Mastitis Research Network. Overall, 6,213 (6.3%) of 98,233 quarter-milk samples from 5,149 cows and 20,305 udder quarters were associated with an NAS IMI. Of the 6,213 phenotypically identified NAS isolates, 5,509 (89%) were stored by the Canadian Bovine Mastitis Research Network Mastitis Pathogen Collection and characterized using partial sequencing of the rpoB housekeeping gene, confirming 5,434 isolates as NAS. Prevalence of each NAS species IMI was estimated using Bayesian models, with presence of a specific NAS species as the outcome. Overall quarter-level NAS IMI prevalence was 26%. The most prevalent species causing IMI were Staphylococcus chromogenes (13%), Staphylococcus simulans (4%), Staphylococcus haemolyticus (3%), Staphylococcus xylosus (2%), and Staphylococcus epidermidis (1%). The prevalence of NAS IMI as a group was highest in first-parity heifers and was evenly distributed throughout cows in parities ≥2. The IMI prevalence of some species such as S. chromogenes, S. simulans, and S. epidermidis differed among parities. Overall prevalence of NAS IMI was 35% at calving, decreased over the next 10 d, and then gradually increased until the end of lactation. The prevalence of S. chromogenes, Staphylococcus gallinarum, Staphylococcus cohnii, and Staphylococcus capitis was highest at calving, whereas the prevalence of S. chromogenes, S. haemolyticus, S. xylosus, and S. cohnii increased during lactation. Although the overall prevalence of NAS IMI was similar across barn types, the prevalence of S. simulans, S. xylosus, S. cohnii, Staphylococcus saprophyticus, S. capitis, and Staphylococcus arlettae IMI was higher in tie-stall barns; the prevalence of S. epidermidis IMI was lowest; and the prevalence of S. chromogenes and Staphylococcus sciuri IMI was highest in bedded-pack barns. Staphylococcus simulans, S. epidermidis, S. xylosus, and S. cohnii IMI were more prevalent in herds with intermediate to high bulk milk somatic cell count (BMSCC) and S. haemolyticus IMI was more prevalent in herds with high BMSCC, whereas other common NAS species IMI were equally prevalent in all 3 BMSCC categories. Distribution of NAS species IMI differed among the 4 regions of Canada. In conclusion, distribution differed considerably among NAS species IMI; therefore, accurate identification (species level) is essential for studying NAS epidemiology

Radiosynthesis and evaluation of talazoparib and its derivatives as PARP-1-targeting agents

Poly (ADP-ribose) polymerase-1 (PARP-1) is a critical enzyme in the DNA repair process and the target of several FDA-approved inhibitors. Several of these inhibitors have been radiolabeled for non-invasive imaging of PARP-1 expression or targeted radiotherapy of PARP-1 expressing tumors. In particular, derivatives of olaparib and rucaparib, which have reduced trapping potency by PARP-1 compared to talazoparib, have been radiolabeled for these purposes. Here, we report the first radiosynthesis of